Integrin alpha 10 beta 1 (AA 23-1122) (Active) protein (His tag)

N° du produit ABIN6938847

Protéine Recombinant Integrin alpha 10 beta 1 exprimée dans HEK-293 Cells.

Aperçu rapide pour Integrin alpha 10 beta 1 (AA 23-1122) (Active) protein (His tag) (ABIN6938847)

Antigène: Integrin alpha 10 beta 1

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Pureté: >95 % as determined by SDS-PAGE.

Détail du produit

Attributs du protein: AA 23-1122

Purification/Conjugué: His tag

Séquence: AA 23-1122

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 150 mM NaCl, pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Détail du antigène

Antigène: Integrin alpha 10 beta 1

Sujet: Human integrin alpha(10)I domain as a recombinant protein to reveal its ligand binding specificity. In general, alpha(10)I did recognize collagen types I-VI and laminin-1 in a Mg(2+)-dependent manner, whereas its binding to tenascin was only slightly better than to albumin. Alpha 10 beta 1 is a known collagen-binding I domain integrin, in addition to α1β1, α2β1 and α11β1. GROGER found in the N-terminal domain of collagens I and III, is only weakly recognised by α10β1, an important collagen receptor on chondrocytes, contrasting with the other collagen-binding integrins.

Poids moléculaire: 126.6 kDa (ITGA10) & 83.7 kDa (ITGB1)