CXCL10 Protein (AA 22-98)

N° du produit ABIN6952220

Détail du produit

Antigène: CXCL10 (Chemokine (C-X-C Motif) Ligand 10 (CXCL10))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 22-98

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Cell Migration Assay (CMA)

Séquence: VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP

Attributs du produit: Recombinant Human CXCL10 (IP-10)

niveau d'endotoxine: <0.01 EU per 1μg of the protein by the LAL method

Biological Activity Comment: EC50 = 6.3 nM determined by Migration Assay in cells expressing recombinant CXCR3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water

Stock: -20 °C,-80 °C

Stockage commentaire: 12 months from date of receipt, -20 to -70 °C as supplied.
Suggest to use immediately after reconstitution
1 month at -20 to -70 °C under sterile conditions after reconstitution.

Date de péremption: 12 months

Détail du antigène

Antigène: CXCL10 (Chemokine (C-X-C Motif) Ligand 10 (CXCL10))

Autre désignation: CXCL10 (IP-10) (CXCL10 Produits)

Synonymes: CXCL10 Protein, C7 Protein, IFI10 Protein, INP10 Protein, IP-10 Protein, SCYB10 Protein, crg-2 Protein, gIP-10 Protein, mob-1 Protein, CRG-2 Protein, IP10 Protein, Ifi10 Protein, Scyb10 Protein, C-X-C motif chemokine ligand 10 Protein, C-X-C motif chemokine 10 Protein, chemokine (C-X-C motif) ligand 10 Protein, CXCL10 Protein, cxl10 Protein, Cxcl10 Protein

Sujet: CXCL10 (IP-10) was originally identified as an IFN-gamma-inducible gene in endothelial, fibroblasts and monocytes cells. IP-10 is considered a member of the CXC chemokine subfamily from its protein sequence which includes the four conserved cysteine residues present in CXC chemokines. IP-10 signals through the CXCR3 receptor to selectively attract Th1 lymphocytes and monocytes. It also has angiostatic and mitogenic properties on vascular smooth muscle cells. A diverse population of cell types rapidly increases transcription of mRNA encoding IP-10, which suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response.

Poids moléculaire: 8.646 kDa

UniProt: P02778