PD-L1 Protein (His tag)

N° du produit ABIN7121291

Cette protéine Recombinant PD-L1 est produite dans HEK-293 Cells.

Aperçu rapide pour PD-L1 Protein (His tag) (ABIN7121291)

Antigène: PD-L1 (CD274 (PD-L1))

Type de proteíne: Recombinant

Origine: Chien

Source: HEK-293 Cells

Pureté: >90 % as determined by SDS-PAGE.

Classe de qualité: MALS verified

Détail du produit

Purification/Conjugué: Cette PD-L1 protéine est marqué à la His tag.

Fonction: Canine PD-L1 / B7-H1 Protein, His Tag (MALS verified)

Séquence: Phe 19 - Arg 236

Attributs du produit: Canine PD-L1, His Tag (PDL-C52H4) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Arg 236 (Accession # E2RKZ5-1).

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Indications d'application: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.6 kDa. The protein migrates as 35-50 kDa under reducing (R) condition due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: PD-L1 (CD274 (PD-L1))

Autre désignation: PD-L1 / B7-H1

Sujet: Synonyms: PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1,
Description: Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.

Poids moléculaire: 26.6 kDa

NCBI Accession: NP_001278901

Pathways: Cancer Immune Checkpoints