SSTR2 Protein-VLP

N° du produit ABIN7199157

Protéine VLP SSTR2 exprimée dans HEK-293 Cells.

Aperçu rapide pour SSTR2 Protein-VLP (ABIN7199157)

Antigène: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Type de proteíne: VLP

Origine: Humain

Source: HEK-293 Cells

Pureté: >80 % as determined by SDS-PAGE.

Détail du produit

Fonction: Human SSTR2 Full Length Protein-VLP (HEK293)

Séquence: Met 1 - Ile 369

Attributs du produit: Human SSTR2 Full Length Protein-VLP is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ile 369 (Accession # P30874-1).

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Ingrédients: Virus-like particles(VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrance Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.
The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.

Information d'application

Indications d'application: The protein has a calculated MW of 45.3 kDa.

Commentaires:

Virus-like particles (VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrance Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.
The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4

Stock: -80 °C

Stockage commentaire: -70°C

Détail du antigène

Antigène: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Autre désignation: SSTR2 Protein-VLP

Sujet: Synonyms: Smstr2,Somatostatin R2,somatostatin receptor 2,somatostatin receptor type 2,SomatostatinR2,SRIF-1,SS2R,SS-2-R,SS2-R,SST2,SSTR2,
Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an invaluable drug target for the pharmacological management of pituitary adenomas and neuroendocrine tumors. Somatostatin receptors (SSTR1, 2A and B, 3, 4 and 5) belong to the G protein coupled receptor family and have a wide expression pattern in both normal tissues and solid tumors. Investigating the function of each SSTR in several tumor types has provided a wealth of information about the common but also distinct signaling cascades that suppress tumor cell proliferation, survival and angiogenesis. This provided the rationale for developing multireceptor-targeted somatostatin analogs and combination therapies with signaling-targeted agents such as inhibitors of the mammalian (or mechanistic) target of rapamycin (mTOR). The ability of SSTR to internalize and the development of rabiolabeled somatostatin analogs have improved the diagnosis and treatment of neuroendocrine tumors.

Poids moléculaire: 45.3 kDa