AARS Protein (His tag)

N° du produit ABIN7320298

Cette protéine Recombinant AARS est exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour AARS Protein (His tag) (ABIN7320298)

Antigène: AARS (Alanyl-tRNA Synthetase (AARS))

Type de proteíne: Recombinant

Origine: Souris

Source: Baculovirus infected Insect Cells

Pureté: > 88 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette AARS protéine est marqué à la His tag.

Fonction: Recombinant Mouse AARS/alanyl-tRNA synthetase Protein (His Tag)

Séquence: Met 1-Asn 968

Attributs du produit: A DNA sequence encoding the mouse AARS (Q8BGQ7) (Met 1-Asn 968) was fused with a polyhistidine tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: AARS (Alanyl-tRNA Synthetase (AARS))

Autre désignation: AARS/alanyl-tRNA synthetase

Sujet:

Background: Alanyl-tRNA synthetase (AARS) belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. This enzyme participates in alanine and aspartate metabolism and aminoacyl-tRNA biosynthesis. Alanyl-tRNA synthetase (AlaRS) catalyzes synthesis of Ala-tRNA (Ala) and hydrolysis of mis-acylated Ser- and Gly-tRNA (Ala) at 2 different catalytic sites. Their role is not confined to catalyze the attachment of amino acids to transfer RNAs and thereby establish the rules of genetic code by virtue of matching the nucleotide triplet of anticodon with cognate amino acid. Under apoptotic conditions in cell culture, the full-length enzyme is secreted, and the two cytokine activities can be generated by leukocyte elastase, an extracellular protease. Secretion of this tRNA synthetase may contribute to apoptosis both by arresting translation and producing needed cytokines. This protein could be an attractive target of drugs against bacterial, fungal and parasitic infections. 

Synonym: AI316495;C76919;sti

Poids moléculaire: 108.3 kDa

UniProt: Q8BGQ7