Cadherin 8 Protein (CDH8) (AA 1-621)

N° du produit ABIN7194516

Cette protéine Recombinant Cadherin 8 est produite dans HEK-293 Cells.

Aperçu rapide pour Cadherin 8 Protein (CDH8) (AA 1-621) (ABIN7194516)

Antigène: Cadherin 8 (CDH8)

Type de proteíne: Recombinant

Origine: Rat

Source: HEK-293 Cells

Pureté: > 80 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 1-621

Fonction: Recombinant Rat Cadherin-8/CDH8 Protein

Séquence: Met1-Met621

Attributs du produit: A DNA sequence encoding the rat CDH8 (NP_445845.2)(Met1-Met621) was expressed with six amino acids (LEVLFQ) at the C-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Cadherin 8 (CDH8)

Autre désignation: Cadherin-8/CDH8

Sujet: CDH8,Cadherins are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Type I cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of five subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Cadherin 8, also known as CDH 8, is a type II classical cadherin belonging to the cadherin superfamily. As mainly expressed in brain, CDH8 is found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts, and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Human Cadherin 8 is a 799 amino acid single-pass type Itransmembrane protein with a putative 29 aa signal sequence, and a 32 aa propeptide, a 560 aa mature extracellular domain, a 21 aa transmembrane domain and a 157 aa cytoplasmic domain. The human, mouse and rat proteins share approximately 98 % homology.

Poids moléculaire:

Calculated MW: 65.9 kDa

Observed MW: 76-85 kDa

NCBI Accession: NP_445845

UniProt: A0A8I6AFP6

Pathways: Cell-Cell Junction Organization