CTSA Protein (His tag)

N° du produit ABIN7320306

Cette protéine Recombinant CTSA est produite dans HEK-293 Cells.

Aperçu rapide pour CTSA Protein (His tag) (ABIN7320306)

Antigène: CTSA (Cathepsin A (CTSA))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 96 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette CTSA protéine est marqué à la His tag.

Fonction: Recombinant Mouse Cathepsin A/CTSA Protein (His Tag)

Séquence: Met 1-Tyr 474

Attributs du produit: A DNA sequence encoding the mouse CTSA (P16675-1) (Met 1-Tyr 474) was expressed, with a C-terminal polyhistidine tag.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 25 mM Tris, 0.3M NaCl, pH 8.0

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CTSA (Cathepsin A (CTSA))

Autre désignation: Cathepsin A/CTSA

Sujet:

Background: Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against the rapid proteolytic degradation. Cathepsin A is a multicatalytic enzyme with deamidase and esterase in addition to carboxypeptidase activities. It was recently identified in human platelets as deamidase. In vitro, it hydrolyzes a variety of bioactive peptide hormones including tachykinins, suggesting that extralysosomal cathepsin A plays a role in regulation of bioactive peptide functions. It is a member of the alpha/beta hydrolase fold family and has been suggested to share a common ancestral relationship with other alpha/beta hydrolase fold enzymes, such as cholinesterases. Cathepsin A defects are linked to multiple forms of Galactosialidosis with a combined secondary deficiency of beta-galactosidase and neuraminidase. Cathepsin A is a key molecule in the onset of galactosialidosis and also highlight the therapeutic acts in vivo as an endothelin-1-inactivating enzyme and strongly confirm a crucial role of this enzyme in effective elastic fiber formation.

Synonym: AU019505,PPCA,Ppgb

Poids moléculaire: 52.8 kDa