Cathepsin D Protein (CTSD) (His tag)

N° du produit ABIN7318253

Protéine Recombinant Cathepsin D exprimée dans Human Cells.

Aperçu rapide pour Cathepsin D Protein (CTSD) (His tag) (ABIN7318253)

Antigène: Cathepsin D (CTSD)

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette Cathepsin D protéine est marqué à la His tag.

Fonction: Recombinant Human Cathepsin D/CTSD Protein (His Tag)

Séquence: Leu21-Leu412

Attributs du produit: Recombinant Human Cathepsin D is produced by our Mammalian expression system and the target gene encoding Leu21-Leu412 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, pH 5.5.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: Cathepsin D (CTSD)

Autre désignation: Cathepsin D/CTSD

Sujet:

Background: The protein acid protease active in intracellular protein breakdown and involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. It is specificity similar to, but narrower than, that of pepsin A and it does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. It consists of a light chain and a heavy chain and expressed in the aorta extrcellular space. The Val-58 allele is significantly overrepresented in demented patients (11.8 % ) compared with non-demented controls (4.9 %). Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers.It belongs to the peptidase A1 family

Synonym: Cathepsin D, CTSD,CLN10,CPSD,HEL-S-130P

Poids moléculaire: 43.8 kDa

UniProt: P07339

Pathways: Peptide Hormone Metabolism