CD16 Protein (CD16) (His tag)

N° du produit ABIN7320834

Cette protéine Recombinant CD16 est produite dans Human Cells.

Aperçu rapide pour CD16 Protein (CD16) (His tag) (ABIN7320834)

Antigène: CD16

Type de proteíne: Recombinant

Origine: Souris

Source: Human Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette CD16 protéine est marqué à la His tag.

Fonction: Recombinant Mouse CD16/FCGR3 Protein (His Tag)

Séquence: Leu32-Thr215

Attributs du produit: Recombinant Mouse CD16 is produced by our Mammalian expression system and the target gene encoding Leu32-Thr215 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD16

Autre désignation: CD16/FCGR3

Sujet:

Background: Low affinity immunoglobulin gamma Fc region receptor III (Fc gamma RIII/CD16) is a member of the Ig superfamily. Based on close relationships in their extracellular domains, the Fc gamma Rs have been divided into three classes composing of Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. Mouse CD16 is a type I transmembrane protein having two extracellular Ig-like domains consisting of immunoglobulin domain, repeat, signa and transmembrane, transmembrane helix. It is expressed on a variety of myeloid and lymphoid cells and associates with Fc R gamma to deliver an activating signal upon ligand binding. Fcgr3 is IgG binding and activation or inhibition of immune responses such as antibody-dependent cellular cytotoxicity, phagocytosis, cell surface receptor signaling pathway and positive regulation of type I/IIa/III hypersensitivity.

Synonym: Low affinity immunoglobulin gamma Fc region receptor III, Fcgr3, Fc gamma Receptor III, CD-antigen 16, CD16, FcRIII, IgG Fc receptor III

Poids moléculaire: 21.9 kDa

UniProt: Q5D5I8

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process