CD69 Protein (CD69) (Fc Tag,ECD)

N° du produit ABIN7320166

Protéine Recombinant CD69 exprimée dans HEK-293 Cells.

Aperçu rapide pour CD69 Protein (CD69) (Fc Tag,ECD) (ABIN7320166)

Antigène: CD69

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 90 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette CD69 protéine est marqué à la Fc Tag,ECD.

Fonction: Recombinant Mouse CD69 Protein (Fc tag, ECD)

Séquence: Gly64-Arg199

Attributs du produit: A DNA sequence encoding the mouse Cd69 (NP_001028294.1) (Gly64-Arg199) was expressed with the Fc region of human IgG1 at the N-terminus.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD69

Autre désignation: CD69

Sujet:

Background: Early activation antigen CD69, also known as activation inducer molecule (AIM), is a single-pass type II membrane protein. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. It is one of the earliest cell surface antigens expressed by T cells following activation. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. CD69 is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator , potentially important in the activation and differentiation of a wide variety of hematopoietic cells. This membrane molecule transiently expresses on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients.

Synonym: 5830438K24Rik,AI452015,AIM,VEA,CLEC2C

Poids moléculaire: 44.1 kDa

NCBI Accession: NP_001028294