CD84 Protein (CD84) (His tag)

N° du produit ABIN7320156

Protéine Recombinant CD84 exprimée dans HEK-293 Cells.

Aperçu rapide pour CD84 Protein (CD84) (His tag) (ABIN7320156)

Antigène: CD84

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: HEK-293 Cells

Application: ELISA

Pureté: > 97 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette CD84 protéine est marqué à la His tag.

Fonction: Recombinant Mouse SLAMF5/CD84 Protein (His Tag)

Séquence: Met 1-Val 221

Attributs du produit: A DNA sequence encoding the mouse CD84 isoform 1 (Q18PI6-1) extracellular domain (Met 1-Val 221) was expressed, with a polyhistidine tag at the C-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: CD84

Autre désignation: SLAMF5/CD84

Sujet: CD84,CD84 antigen,CD84 Molecule,Cd84,Leukocyte differentiation antigen CD84,Ly-9B,SLAM family member 5,SLAMF5,Signaling lymphocytic activation molecule 5,The CD2 family receptors are type I transmembrane glycoproteins belonging to immunoglobulin (Ig) superfamily characterized by a membrane-proximal Ig constant 2 (C2) domain and a membrane-distal variable (V) domain that is responsible for ligand recognition. CD84, also known as LY9B and SLAMF5, is a homophilic member of the SLAM (signaling lymphocyte activation molecule) subfamily of the CD2 family. The SLAM family receptorsmediate signal transduction through the interaction of its ITSM (immunoreceptor tyrosine-based switch motifs) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. The CD84-CD84 interaction was independent of its cytoplasmic tail. Thus, CD84 is its own ligand and acts as a costimulatory molecule. CD84 is expressed on cells from almost all hematopoietic lineages and on CD34+ hematopoietic progenitor cells, suggesting that CD84 serves as a marker for committed hematopoietic progenitor cells.

Poids moléculaire: 24 kDa

ID gène: 12523

UniProt: Q18PI6