CD99 Protein (CD99) (His tag)

N° du produit ABIN7319789

Cette protéine Recombinant CD99 est produite dans Human Cells.

Aperçu rapide pour CD99 Protein (CD99) (His tag) (ABIN7319789)

Antigène: CD99

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Pureté: >90 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette CD99 protéine est marqué à la His tag.

Fonction: Recombinant Human CD99/MIC2 (C-6His)

Séquence: Asp23-Asp122

Attributs du produit: Recombinant Human CD99 is produced by our Mammalian expression system and the target gene encoding Asp23-Asp122 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: CD99

Autre désignation: CD99/MIC2

Classe de substances: Viral Protein

Sujet:

Background: CD99 is a type I transmembrane glycoprotein and the founding member of the CD99 family of molecules. The extracellular domain of CD99 contains no identifiable motifs, its cytoplasmic region, although short, does have signal transduction capability. Cells known to express CD99 include fibroblasts, neutrophils, T cells, double positive thymocytes, CD34+ stem cells, monocytes and endothelial cells. Two types of CD99 isoforms have been classified. Native human CD99 is referred to as the long, or type I isoform. The best studied type II isoform shows an Asp-Gly substitution for the C terminal 27 amino acids. The type I and II isoforms have distinctive signal transduction pathways (FAKsrc for type I PI3K plus srcERK1/2 for type II), and mediate clearly different biological outcomes. Homophilic interaction between CD99 on the neutrophil and CD99 on the endothelial cell regulates the transendothelial migration of neutrophils during inflammation. Human CD99 has 48 % aa sequence identity to mouse CD99.

Synonym: CD99 Antigen, 12E7, E2 Antigen, Protein MIC2, T-Cell Surface Glycoprotein E2, CD99, MIC2, MIC2X, MIC2Y

Poids moléculaire: 11.13 kDa

UniProt: P14209