DPP7 Protein (His tag)

N° du produit ABIN7195431

Cette protéine Recombinant DPP7 est produite dans HEK-293 Cells.

Aperçu rapide pour DPP7 Protein (His tag) (ABIN7195431)

Antigène: DPP7 (Dipeptidyl-Peptidase 7 (DPP7))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: > 98 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette DPP7 protéine est marqué à la His tag.

Fonction: Recombinant Human DPP7/DPPII/DPP2 Protein (His Tag)

Séquence: Met 1-Leu 492

Attributs du produit: A DNA sequence encoding the human DPPII (NP_037511.2) (Met 1-Leu 492) with a C-terminal polyhistidine tag was expressed.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: DPP7 (Dipeptidyl-Peptidase 7 (DPP7))

Autre désignation: DPP7/DPPII/DPP2

Sujet: DPP2,DPPII,QPP,DPP7 (dipeptidylpeptidase 7), also known as DPPII and DPP2, is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. Dipeptidyl peptidases (DPPs) have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. It localizes to lysosomes. DPP7 localizes to lysosomes and exists as a homodimer via its leucine zipper motif and is involved in the degradation of oligopeptides. In response to calcium release, it can be secreted in its active form. It is essential for lymphocyte survival, as the inhibition of DPP7 results in quiescent cell apoptosis.

Poids moléculaire:

Calculated MW: 53.6 kDa

Observed MW: 60 kDa

ID gène: 29952

NCBI Accession: NP_037511

UniProt: Q9UHL4