DPP10 Protein (His tag)

N° du produit ABIN7317488

Protéine Recombinant DPP10 exprimée dans HEK-293 Cells.

Aperçu rapide pour DPP10 Protein (His tag) (ABIN7317488)

Antigène: DPP10 (Dipeptidylpeptidase 10 (DPP10))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: > 97 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette DPP10 protéine est marqué à la His tag.

Fonction: Recombinant Human DPP10/DPRP3 Protein (His Tag)

Séquence: Leu 56-Glu 796

Attributs du produit: A DNA sequence encoding the human DPP10 isoform 1 (Q8N608-1) extracellular domain (Leu 56-Glu 796) was expressed, with a polyhistidine tag at the N-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: DPP10 (Dipeptidylpeptidase 10 (DPP10))

Autre désignation: DPP10/DPRP3

Sujet: DPL2,DPPY,DPRP-3,DPRP3,Inactive dipeptidyl peptidase 10, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP10, is a single-pass type II membrane protein which belongs to thepeptidase S9B family.DPPIV subfamily. It may modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. DPP10 / DPRP3 has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Genetic variations in DPP10 are associated with susceptibility to asthma (ASTHMA). The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.

Poids moléculaire:

Calculated MW: 87.4 kDa

Observed MW: 90-110 kDa

ID gène: 57628

UniProt: Q8N608