COL18A1 Protein (His tag)

N° du produit ABIN7320492

Cette protéine Recombinant COL18A1 est produite dans Human Cells.

Aperçu rapide pour COL18A1 Protein (His tag) (ABIN7320492)

Antigène: COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))

Type de proteíne: Recombinant

Origine: Souris

Source: Human Cells

Pureté: > 90 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette COL18A1 protéine est marqué à la His tag.

Fonction: Recombinant Mouse COL18A1/Endostatin Protein (His Tag)

Séquence: His1591-Lys1774

Attributs du produit: Recombinant Mouse Collagen alpha-1(XVIII) chain is produced by our Mammalian expression system and the target gene encoding His1591-Lys1774 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: COL18A1 (Collagen, Type XVIII, alpha 1 (COL18A1))

Autre désignation: COL18A1/Endostatin

Classe de substances: Chemical

Sujet:

Background: Endostatin, an endogenous non-glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP-2 and MMP-9, and cathepsins S, B and L. The N-terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti-endothelial and anti-tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse Endostatin shares 96 % aa sequence identity with rat and 85-87 % with human, bovine and equine Endostatin. It is predominantly expressed in liver, kidney, lung, skeletal muscle and testis. Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis. It is also thought to down-regulate angiogenesis by blocking VEGF-induced endothelial cell migration. Endostatin may also be involved with down-regulation of angiogenesis after establishment of placental circulation in the pregnant uterus.

Synonym: antiangiogenic agent,COL18A1,collagen alpha-1(XVIII)chain, collagen,type XVIII,Endostatin

Poids moléculaire: 21.2 kDa

UniProt: P39061