QPCT Protein (His tag)

N° du produit ABIN7195939

Cette protéine Recombinant QPCT est exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour QPCT Protein (His tag) (ABIN7195939)

Antigène: QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette QPCT protéine est marqué à la His tag.

Fonction: Recombinant Human Glutaminyl cyclase/QPCT Protein (His Tag)

Séquence: Ala33-Leu361

Attributs du produit: A DNA sequence encoding the human QPCT (Q16769-1) (Ala33-Leu361) was fused with a polyhistide tag at the N-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))

Autre désignation: Glutaminyl cyclase/QPCT

Sujet:

Background: Glutaminyl cyclase, also known as QPCT, can promote the N-terminal cyclization reaction of N-terminal pyroglutamate(pGlu). The pGlu formation from its glutaminyl precursor is required in the maturation of numerous bioactive peptides, while the aberrant formation of pGlu may be related to several pathological processes, such as osteoporosis and amyloidotic diseases. Glutaminyl cyclase's structure reveals an alpha/beta scaffold akin to that of two-zinc exopeptidases but with several insertions and deletions, particularly in the active-site region. Glutaminyl cyclase's amino acid sequence of this enzyme is 86 % identical to that of bovine glutaminyl cyclase. It is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides.

Synonym: GCT,QC,sQC

Poids moléculaire: 39.7 kDa