GAMT Protein (His tag)

N° du produit ABIN7318555

Cette protéine Recombinant GAMT est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour GAMT Protein (His tag) (ABIN7318555)

Antigène: GAMT (Guanidinoacetate N-Methyltransferase (GAMT))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 90 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette GAMT protéine est marqué à la His tag.

Fonction: Recombinant Human GAMT Protein (His Tag)

Séquence: Met 1-Gly236

Attributs du produit: Recombinant Human Guanidinoacetate N-methyltransferase is produced by our E.coli expression system and the target gene encoding Met1-Gly236 is expressed with a 6His tag at the N-terminus, 6His tag at the C-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 1 mM DTT, pH 8.0.

Agent conservateur: Dithiothreitol (DTT)

Précaution d'utilisation: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: GAMT (Guanidinoacetate N-Methyltransferase (GAMT))

Autre désignation: GAMT

Sujet: GAMT,Guanidinoacetate N-methyltransferase,PIG2,TP53I2,GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances, severe depletion of creatine/phosphocreatine in the brain, and accumulation of guanidinoacetic acid in brain and body fluids.

Poids moléculaire:

Calculated MW: 29.5 kDa

Observed MW: 27-32 kDa

ID gène: 2593

UniProt: Q14353