IL-22 Protein (AA 34-179)

N° du produit ABIN7319555

Cette protéine Recombinant IL-22 est exprimée dans HEK-293 Cells.

Aperçu rapide pour IL-22 Protein (AA 34-179) (ABIN7319555)

Antigène: IL-22 (IL22) (Interleukin 22 (IL22))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 34-179

Fonction: Recombinant Human Interleukin-22/IL-22 Protein

Séquence: Ala34-Ile179

Attributs du produit: Recombinant Human Interleukin-22 is produced by our Mammalian expression system and the target gene encoding Ala34-Ile179 is expressed.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: IL-22 (IL22) (Interleukin 22 (IL22))

Autre désignation: Interleukin-22/IL-22

Sujet: UNQ,IL-D,Interleukin,Cytokine Zcyto,TIFIL,zcyto,IL22,IL-22,IL-D110,IL-TIF,ILTIF,TIFIL-23,TIFa,zcyto18,UNQ3099/PRO10096,UNQ3099,Interleukin-22,Cytokine Zcyto18,IL-10-related T-cell-derived-inducible factor,PRO10096,IL-D110,ILTIF,IL-TIF,TIFa,TIFIL-23,zcyto18,Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.

Poids moléculaire:

Calculated MW: 17.9 kDa

Observed MW: 25-35 kDa

ID gène: 50616

UniProt: Q9GZX6