Latexin Protein (LXN) (His tag)

N° du produit ABIN7196736

Cette protéine Recombinant Latexin est produite dans Escherichia coli (E. coli).

Aperçu rapide pour Latexin Protein (LXN) (His tag) (ABIN7196736)

Antigène: Latexin (LXN)

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 97 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette Latexin protéine est marqué à la His tag.

Fonction: Recombinant Human Latexin/LXN Protein (His Tag)

Séquence: Glu 2-Glu222

Attributs du produit: A DNA sequence encoding the human Latexin (NP_064554.3) (Glu 2-Glu222) was expressed, fused with a polyhistidine tag at the N-terminus.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 20 mM HEPES, 0.1M KCl, pH 7.5

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Latexin (LXN)

Autre désignation: Latexin/LXN

Sujet:

Background: Latexin; also known as endogenous carboxypeptidase inhibitor; tissue carboxypeptidase inhibitor; TCI; ECI and LXN; is a cytoplasm protein which belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in heart; prostate; ovary; kidney; pancreas; and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional specification of the neocortex in development in rats. The 222 amino acid latexin in human shows different expression distribution with high levels in heart; prostate; ovary; kidney; pancreas; and colon; but only moderate or low levels in other tissues including brain. Latexin is also expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets; and thus is suggested to play a role in inflammation and innate immunity pathways. Despite of the non-detectable sequence similarity with plant and parasite inhibitors; Latexin is related to a human putative tumor suppressor protein; TIG1. In addition; Latexin is also implicated in Alzheimer's disease.

Synonym: ECI;TCI

Poids moléculaire: 26.8 kDa

NCBI Accession: NP_064554