LGMN Protein (His tag)

N° du produit ABIN7320693

Cette protéine Recombinant LGMN est exprimée dans Human Cells.

Aperçu rapide pour LGMN Protein (His tag) (ABIN7320693)

Antigène: LGMN (Legumain (LGMN))

Type de proteíne: Recombinant

Origine: Souris

Source: Human Cells

Pureté: > 95 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette LGMN protéine est marqué à la His tag.

Fonction: Recombinant Mouse Legumain/LGMN Protein (His Tag)

Séquence: Val 18-Tyr 435

Attributs du produit: Recombinant Mouse Legumain/Asparaginyl Endopeptidase is produced by our Mammalian expression system and the target gene encoding Val18-Tyr435 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl,20 % Glycerol, pH 8.0.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: LGMN (Legumain (LGMN))

Autre désignation: Legumain/LGMN

Sujet:

Background: Mouse Legumain,also known as LGMN, is a cysteine protease belonging to peptidase family C13 and is expressed in kidney and placenta abundantly. LGMN has a strict specificity for hydrolysis of asparaginyl bonds. It can also cleave aspartyl bonds slowly, especially under acidic conditions. The mammalian legumain is involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. It plays a role in the regulation of cell proliferation via its role in EGFR degradation. Legumain deficiency causes the accumulation of pro-Cathepsins B, H and L, another group of lysosomal cysteine proteases. Overexpression of Legumain in tumors is significant for invasion/metastasis. Mammalian legumain is inhibited by iodoacetamide and maleimides. Legumain activation appears to be autocatalytic and can be triggered by acidic pH .

Synonym: Legumain,Lgmn,Asparaginyl endopeptidase,Protease cysteine 1,Prsc1,AEP

Poids moléculaire: 48.7 kDa

NCBI Accession: NP_035305

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades