Lipocalin 2 Protein (LCN2) (His tag)

N° du produit ABIN7318826

Cette protéine Recombinant Lipocalin 2 est exprimée dans Human Cells.

Aperçu rapide pour Lipocalin 2 Protein (LCN2) (His tag) (ABIN7318826)

Antigène: Lipocalin 2 (LCN2)

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette Lipocalin 2 protéine est marqué à la His tag.

Fonction: Recombinant Human NGAL/Lipocalin-2 Protein (His Tag, Human Cells)

Séquence: Gln21-Gly198

Attributs du produit: Recombinant Human Neutrophil gelatinase-associated lipocalin is produced by our Mammalian expression system and the target gene encoding Gln21-Gly198 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of PBS, 50 % glycerol, pH 7.4.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: Lipocalin 2 (LCN2)

Autre désignation: NGAL/Lipocalin-2

Sujet:

Background: LCN2 is iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. LCN2 binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. LCN2 is involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. LCN2 is involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Synonym: Neutrophil gelatinase-associated lipocalin, NGAL, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2, p25, HNL, NGAL

Poids moléculaire: 21.6 kDa

UniProt: P80188

Pathways: Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis