Lipocalin 2 Protein (LCN2) (His tag)

N° du produit ABIN7320752

Cette protéine Recombinant Lipocalin 2 est exprimée dans Human Cells.

Aperçu rapide pour Lipocalin 2 Protein (LCN2) (His tag) (ABIN7320752)

Antigène: Lipocalin 2 (LCN2)

Type de proteíne: Recombinant

Origine: Souris

Source: Human Cells

Pureté: > 95 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette Lipocalin 2 protéine est marqué à la His tag.

Fonction: Recombinant Mouse NGAL/Lipocalin-2 Protein (His Tag)

Séquence: Gln21-Asn200

Attributs du produit: Recombinant Mouse Neutrophil gelatinase-associated lipocalin is produced by our Mammalian expression system and the target gene encoding Gln21-Asn200 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, 10 % Glycerol, pH 5.5.

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Détail du antigène

Antigène: Lipocalin 2 (LCN2)

Autre désignation: NGAL/Lipocalin-2

Sujet:

Background: Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes with matrix metalloproteinase-9 (MMP-9) through disulfide bonds. Similar to other lipocalin family members, Lipocalin-2 is involved in diverse cellular processes, including the transport of small hydrophobic molecules, protection of MMP-9 from proteolytic degradation, and cell signaling. Furthermore, Lipocalin-2 can tightly bind to bacterial siderophore through a cell surface receptor, possibly serving as a potent bacteriostatic agent by sequestering iron, regulating innate immunity and protecting kidney epithelial cells from ischemia-reperfusion injury. This protein is mainly expressed in neutrophils and in lower levels in the kidney, prostate, and epithelia of the respiratory and alimentary tracts. Recent evidence also suggests its role as a biomarker for renal injury and inflammation.

Synonym: Neutrophil gelatinase-associated lipocalin, NGAL, Lipocalin-2, SV-40-induced 24P3 protein, Siderocalin LCN2, p25, LCN2

Poids moléculaire: 21.9 kDa

UniProt: P11672

Pathways: Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis