MVK Protein (His-GST)
Aperçu rapide pour MVK Protein (His-GST) (ABIN7197016)
Antigène
Voir toutes MVK ProtéinesType de proteíne
Origine
Source
Pureté
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Purification/Conjugué
- Cette MVK protéine est marqué à la His-GST.
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Fonction
- Recombinant Human MVK/Mevalonate kinase Protein (His & GST Tag)
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Séquence
- Met 1-Leu 396
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Attributs du produit
- A DNA sequence encoding the human MVK (Q03426) (Met1-Leu396) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Stérilité
- 0.2 μm filtered
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niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Mevalonate Kinase (MVK) (AA 1-395) protein (His tag)
custom-made MVK Origine: Souris Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Mevalonate Kinase (MVK) (AA 1-396) protein (His tag)custom-made MVK Origine: Humain Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Mevalonate Kinase (MVK) (AA 1-396) protein (His tag)MVK Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant > 90 % SDS
Mevalonate Kinase (MVK) proteinMVK Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant SDS
Mevalonate Kinase (MVK) (AA 1-396) protein (GST tag)MVK Origine: Humain Hôte: Wheat germ Recombinant AP, AA, ELISA, WB
Mevalonate Kinase (MVK) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)MVK Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Mevalonate Kinase (MVK) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)MVK Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 2 mM DTT, pH 7.4, 10 % glycerol
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Agent conservateur
- Dithiothreitol (DTT)
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Précaution d'utilisation
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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Stockage commentaire
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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Date de péremption
- 6 months
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- MVK (Mevalonate Kinase (MVK))
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Autre désignation
- MVK/Mevalonate kinase
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Sujet
- LRBP,MK,MVLK,POROK3,Mevalonate kinase belongs to the GHMP kinase family, Mevalonate kinase subfamily. It can be found in a wide variety of organisms from bacteria to mammals. Mevalonate kinase may be a regulatory site in cholesterol biosynthetic pathway. Defects in mevalonate kinase can cause mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia. Defects in mevalonate kinase can also cause hyperimmunoglobulinemia D and periodic fever syndrome (HIDS). HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis.
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Poids moléculaire
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Calculated MW: 70.2 kDa
Observed MW: 47 kDa
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ID gène
- 4598
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UniProt
- Q03426
Antigène
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