Neurexin 3 Protein (NRXN3) (His tag)

N° du produit ABIN7317470

Cette protéine Recombinant Neurexin 3 est produite dans HEK-293 Cells.

Aperçu rapide pour Neurexin 3 Protein (NRXN3) (His tag) (ABIN7317470)

Antigène: Neurexin 3 (NRXN3)

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: > 94 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette Neurexin 3 protéine est marqué à la His tag.

Fonction: Recombinant Human NRXN3 Protein (His Tag)

Séquence: Met 1-Thr 357

Attributs du produit: A DNA sequence encoding the human NRXN3 beta isoform 2 (NP_620426.2) extracellular domain (Met 1-Thr 357) was expressed, with a polyhistidine tag at the C-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Neurexin 3 (NRXN3)

Autre désignation: NRXN3

Sujet: C14orf60,Neurexin-3-beta, also known as Neurexin III-beta and NRXN3, is a single-pass type I membrane protein which belongs to theneurexin family. It contains onelaminin G-like domain. It is a neuronal cell surface protein that may be involved in cell recognition and cell adhesion. Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes ( NRXN1, NRXN2, NRXN3 ) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms, a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain EGF-like sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. NRXN3 have been linked to genetic predisposition towards a number of conditions such as alcohol or drug addiction, or obesity.

Poids moléculaire:

Calculated MW: 36.0 kDa

Observed MW: 50-60 kDa

ID gène: 9369

NCBI Accession: NP_620426

UniProt: Q9HDB5