Aperçu rapide pour NFASC Protein (Fc Tag) (ABIN7197149)
Antigène
Voir toutes NFASC ProtéinesType de proteíne
Origine
Source
Pureté
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Purification/Conjugué
- Cette NFASC protéine est marqué à la Fc Tag.
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Fonction
- Recombinant Human NFASC/Neurofascin protein (Fc Tag)
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Séquence
- Met 1-Gln939
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Attributs du produit
- A DNA sequence encoding the human NFASC (XP_011507630.1) (Met1-Gln939) was expressed with the Fc region of human IgG1 at the C-terminus.
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Stérilité
- 0.2 μm filtered
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niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Neurofascin (NFASC) (AA 1239-1347) protein (His tag)
NFASC Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. SDS
Neurofascin (NFASC) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)NFASC Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Neurofascin (NFASC) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)NFASC Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
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Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
Stock
- 4 °C,-20 °C,-80 °C
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Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Date de péremption
- 12 months
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- NFASC (Neurofascin (NFASC))
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Autre désignation
- NFASC/Neurofascin
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Sujet
- NF,NRCAML,NFASC, also known as neurofascin, belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. NFASC functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. NFASC links the AIS extracellular matrix to the intracellular cytoskeleton.
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Poids moléculaire
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Calculated MW: 130 kDa
Observed MW: 130 kDa
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ID gène
- 23114
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NCBI Accession
- NP_001005388
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UniProt
- O94856
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Pathways
- Cell-Cell Junction Organization
Antigène
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