Neuroligin 1 Protein (NLGN1) (His tag)

N° du produit ABIN7320172

Cette protéine Recombinant Neuroligin 1 est exprimée dans HEK-293 Cells.

Aperçu rapide pour Neuroligin 1 Protein (NLGN1) (His tag) (ABIN7320172)

Antigène: Neuroligin 1 (NLGN1)

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 97 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette Neuroligin 1 protéine est marqué à la His tag.

Fonction: Recombinant Mouse Neuroligin 1/NLGN1 Protein (His Tag)

Séquence: Met 1-Ser 697

Attributs du produit: A DNA sequence encoding the mouse NLGN1 isoform 1 (Q99K10-1) extracellular domain (Met 1-Ser 697) was expressed, with a C-terminal polyhistidine tag.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Neuroligin 1 (NLGN1)

Autre désignation: Neuroligin 1/NLGN1

Sujet:

Background: Neuroligin 1 (NLGN1) belongs to the type-B carboxylesterase/lipase family, is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion. Neuroligins consist of five members (NLGN1, NLGN2, NLGN3, NLGN4 and NLGN4Y), which interact with beta-neurexins and this interaction is involved in the formation of functional synapses. The extracellular domain of functional Neuroligin 1 associates as a dimer when analyzed by sedimentation equilibrium. Neuroligin 1 has a unique N-linked glycosylation pattern in the neuroligin family, and glycosylation and its processing modify neuroligin activity. Neuroligin 1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. The persistent expression of Neuroligin 1 is required for the maintenance of NMDAR-mediated synaptic transmission, which enables normal development of synaptic plasticity and long-term memory in the amygdala of adult animals.

Synonym: 6330415N05Rik,BB179718,mKIAA1070,NL1,Nlg1

Poids moléculaire: 73.5 kDa

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis