Neuroligin 3 Protein (NLGN3) (His tag)

N° du produit ABIN7317636

Protéine Recombinant Neuroligin 3 exprimée dans HEK-293 Cells.

Aperçu rapide pour Neuroligin 3 Protein (NLGN3) (His tag) (ABIN7317636)

Antigène: Neuroligin 3 (NLGN3)

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: > 92 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette Neuroligin 3 protéine est marqué à la His tag.

Fonction: Recombinant Human Neuroligin-3/NLGN3 Protein (His Tag)

Séquence: Met 1-Ser 689

Attributs du produit: A DNA sequence encoding the human NLGN3 isoform 2 (Q9NZ94-2) extracellular domain (Met 1-Ser 689) was expressed, fused with a polyhistidine tag at the C-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Neuroligin 3 (NLGN3)

Autre désignation: Neuroligin-3/NLGN3

Sujet: HNL3,Neuroligin 3 (NLGN3) is a member of the type-B carboxylesterase/lipase family. Neuroligins (NLGNs) are a family of presumptive postsynaptic cell adhesion molecules. Neuroligins (NLs) constitute a family of cell-surface proteins that interact with neurexins (beta-Nxs), another class of neuronal cell-surface proteins, one of each class functioning together in synapse formation. Neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons. NLGN1 and NLGN2 isoforms are concentrated at glutamatergic and GABAergic synapses, respectively, but the cellular expression and synaptic localization of the endogenous. NLGN3 was enriched in brain, where NLGN3 protein levels increased during postnatal development, coinciding with the peak of synaptogenesis. The NLGN3 is a synaptic adhesion molecule that is a shared component of glutamatergic and GABAergic synapses. Mutations in NLGN3 gene may be associated with autism and Asperger syndrome.

Poids moléculaire:

Calculated MW: 74.0 kDa

Observed MW: 100-110 kDa

ID gène: 54413

UniProt: Q9NZ94

Pathways: Synaptic Membrane