Olfactomedin 4 Protein (OLFM4) (His tag)

N° du produit ABIN7197233

Protéine Recombinant Olfactomedin 4 exprimée dans HEK-293 Cells.

Aperçu rapide pour Olfactomedin 4 Protein (OLFM4) (His tag) (ABIN7197233)

Antigène: Olfactomedin 4 (OLFM4)

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: > 92 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette Olfactomedin 4 protéine est marqué à la His tag.

Fonction: Recombinant Human OLFM4 Protein (His Tag)

Séquence: Met 1-Gln 510

Attributs du produit: A DNA sequence encoding the human OLFM4 (NP_006409.3) (Met 1-Gln 510) was fused with a polyhistidine tag at the C-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Olfactomedin 4 (OLFM4)

Autre désignation: OLFM4

Sujet: Antiapoptotic protein GW112,G-CSF-stimulated clone 1 protein,GW112,OLFM4,OLM4,Olfactomedin-4,hGC-1,hOLfD,Olfactomedin-4, also known as G-CSF-stimulated clone 1 protein, Antiapoptotic protein GW112, and OLFM4, is a secreted protein which contains one olfactomedin-like domain. The OLFM4 gene was recently reported to inhibit various apoptotic pathways and promote proliferation of cancer cells, suggesting that OLFM4 might serve as a diagnostic marker for human cancers. Thus, OLFM4 mRNA might be a useful tool to support the diagnosis of cancer, irrespective of the clinical stages. It is overexpressed in a number of human tumor types, especially in those of the digestive system. GW112 is associated with GRIM-19, a protein known to be involved in regulating cellular apoptosis. Functionally, GW112 could significantly attenuate the ability of GRIM19 to mediate retinoic acid-IFN-beta-mediated cellular apoptosis and apoptosis-related gene expression. In addition, GW112 demonstrated strong antiapoptotic effects in tumor cells treated with other stress exposures such as hydrogen peroxide. Finally, forced overexpression of GW112 in murine prostate tumor cells led to more rapid tumor formation in a syngeneic host. OLFM4 is an important regulator of cell death that plays important roles in tumor cell survival and tumor growth. GW112 has an antiapoptotic property against the cytotoxic agents-induced apoptosis. It suggested that GW112 could be an important mediator in NF kappaB-dependent tumorigenesis of digestive tract tissues.

Poids moléculaire: 56.6 kDa

ID gène: 10562

NCBI Accession: NP_006409

UniProt: Q6UX06