Osteomodulin Protein (OMD) (His tag)

N° du produit ABIN7320274

Cette protéine Recombinant Osteomodulin est exprimée dans HEK-293 Cells.

Aperçu rapide pour Osteomodulin Protein (OMD) (His tag) (ABIN7320274)

Antigène: Osteomodulin (OMD)

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 96 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette Osteomodulin protéine est marqué à la His tag.

Fonction: Recombinant Mouse Osteomodulin/OMD Protein (His Tag)

Séquence: Met 1-Ile 423

Attributs du produit: A DNA sequence encoding the mouse OMD (NP_036180.1) (Met 1-Ile 423) precusor was expressed, with a C-terminal polyhistidine tag.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Osteomodulin (OMD)

Autre désignation: Osteomodulin/OMD

Sujet:

Background: Osteomodulin (OMD), also known as Osteoadherin (OSAD), Keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, and SLRR2C, is a secreted protein which belongs to the small leucine-rich proteoglycan (SLRP) family and Class II subfamily. SLRP family proteins are normally found in extracellular matrices, but Osteomodulin is the only member restricted to mineralized tissues. Osteomodulin is primarily expressed by osteoblasts and might have a role in regulation of mineralization. In bone OSAD has been localized in primary spongiosa within the bovine fetal rib growth plate. Moreover, in situ hybridization has shown expression of OSAD in osteoblasts close to the cartilage and bone border in the growth plate of rat femur. OSAD may play an important role during tooth development and biomineralization of dentin. Osteomodulin is a cell binding keratan sulfate proteoglycan which was recently isolated from mineralized bovine bone and subsequently cloned and sequenced. Osteomodulin may be implicated in biomineralization processes. It has a function in binding of osteoblasts via the alpha (V) beta (3)-integrin. It is likely that Osteomodulin is an osteoblast maturation marker that is induced by osteoclast activity. Osteomodulin is also an early marker for terminally differentiated matrix producing osteoblasts.

Synonym: OSAD,SLRR2C

Poids moléculaire: 48.8 kDa

NCBI Accession: NP_036180

Pathways: Glycosaminoglycan Metabolic Process