PDE9A Protein (His tag)

N° du produit ABIN7317497

Protéine Recombinant PDE9A exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour PDE9A Protein (His tag) (ABIN7317497)

Antigène: PDE9A (phosphodiesterase 9A (PDE9A))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette PDE9A protéine est marqué à la His tag.

Fonction: Recombinant Human PDE9A Protein (His Tag)

Séquence: Pro 181-Lys 506

Attributs du produit: A DNA sequence encoding the human PDE9A (O76083-2) C-terminal segment (Pro 181-Lys 506) was expressed, with a polyhistide tag at the N-terminus.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: PDE9A (phosphodiesterase 9A (PDE9A))

Autre désignation: PDE9A

Sujet:

Background: High affinity cGMP-specific 3';5'-cyclic phosphodiesterase 9A; also known as PDE9A; is a member of the cyclic nucleotide phosphodiesterase family and PDE9 subfamily. PDE9A is expressed in all tissues examined (testis; brain; small intestine; skeletal muscle; heart; lung; thymus; spleen; placenta; kidney; liver; pancreas; ovary and prostate) except blood. Highest levels of PDE9A is in brain; heart; kidney; spleen; prostate and colon. Isoform PDE9A12 is found in prostate. PDE9A mRNA is widely distributed throughout the rat and mouse brain; with the highest expression observed in cerebellar Purkinje cells. PDE9A is the only cGMP-specific PDE with significant expression in the forebrain; and as such is likely to play an important role in NO-cGMP signaling. PDE9A is highly conserved between species and is widely distributed throughout the rodent brain. PDE9A is probably involved in maintenance of low cGMP levels in cells and might play an important role in a variety of brain functions involving cGMP-mediated signal transduction. PDE9A hydrolyzes the second messenger cGMP; which is a key regulator of many important physiological processes. PDE9A represents a novel drug target worthy of further study.

Synonym: HSPDE9A2

Poids moléculaire: 40 kDa