Relaxin 1 Protein (RLN1) (His tag)

N° du produit ABIN7317519

Cette protéine Recombinant Relaxin 1 est exprimée dans HEK-293 Cells.

Aperçu rapide pour Relaxin 1 Protein (RLN1) (His tag) (ABIN7317519)

Antigène: Relaxin 1 (RLN1)

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: > 82 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette Relaxin 1 protéine est marqué à la His tag.

Fonction: Recombinant Human Relaxin-1/RLN1 Protein (His Tag)

Séquence: Met 1-Cys 185

Attributs du produit: A DNA sequence encoding the human RLN1 (NP_008842.1) (Met 1-Cys 185) was fused with a polyhistidine tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Relaxin 1 (RLN1)

Autre désignation: Relaxin-1/RLN1

Sujet:

Background: Relaxin-1, also known as Prorelaxin H1 and RLN1, is a secreted protein which belongs to the insulin family. It is a peptide hormone that was first described in 1926 by Frederick Hisaw. Since its discovery as a reproductive hormone 80 years ago, relaxin has been implicated in a number of pregnancy-related functions involving extracellular matrix (ECM) turnover and collagen degradation. It is now becoming evident that relaxin's ability to reduce matrix synthesis and increase ECM degradation has important implications in several nonreproductive organs, including the heart, lung, kidney, liver and skin. The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity; relaxin-1 (RNL1), relaxin-2 (RNL2) and relaxin-3 ( RNL3), and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6. The functions of relaxin-3, INSL4, INSL5, INSL6 remain uncharacterised. Relaxin-1 / RLN1 is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. Relaxin-1 / RLN1 may be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Relaxin and estrogen appear to play protective roles against airway fibrosis, airway SM thickening, and cardiac hypertrophy. Relaxin may also provide a means to regulate excessive collagen deposition during kidney development and in diseased states characterized by renal fibrosis.

Synonym: bA12D24.3.1;bA12D24.3.2;H1;H1RLX;RLN1;RLXH1

Poids moléculaire: 20 kDa

NCBI Accession: NP_008842