Sclerostin Protein (SOST) (His tag)
Aperçu rapide pour Sclerostin Protein (SOST) (His tag) (ABIN7197841)
Antigène
Voir toutes Sclerostin (SOST) ProtéinesType de proteíne
Origine
Source
Pureté
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Purification/Conjugué
- Cette Sclerostin protéine est marqué à la His tag.
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Fonction
- Recombinant Rat Sclerostin/SOST Protein (His Tag)
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Séquence
- Met 1-Tyr 213
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Attributs du produit
- A DNA sequence encoding the rat SOST (NP_085073.1) (Met 1-Tyr 213) was expressed, fused with a polyhistidine tag at the C-terminus.
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Stérilité
- 0.2 μm filtered
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niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Sclerostin (SOST) (AA 24-213) protein (His-Avi Tag)
SOST Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Sclerostin (SOST) (AA 24-213) (Active) protein (Biotin,His-Avi Tag)SOST Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Sclerostin (SOST) (AA 69-258) (Active) protein (His tag)SOST Origine: Cynomolgus Hôte: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE Active
Sclerostin (SOST) (AA 24-211) protein (His tag)SOST Origine: Souris Hôte: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Sclerostin (SOST) (AA 24-213) protein (His tag,Biotin)SOST Origine: Humain Hôte: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
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Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
Stock
- 4 °C,-20 °C,-80 °C
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Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Date de péremption
- 12 months
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- Sclerostin (SOST)
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Autre désignation
- Sclerostin/SOST
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Sujet
- SOST,Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteeoblasts differentiated for 21 days, and was originally identified as an important regulator of bone remodeling, homeostasis, and links bone resorption and bone apposition. Recent studies have revealed that Sclerostin protein inhibits the bone growth probably by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt-induced Frizzled-LRP complex formation.
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Poids moléculaire
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Calculated MW: 23 kDa
Observed MW: 33 kDa
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NCBI Accession
- NP_085073
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UniProt
- A6HJF6
Antigène
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