L-Selectin Protein (His tag)

N° du produit ABIN7197873

Cette protéine Recombinant L-Selectin est produite dans HEK-293 Cells.

Aperçu rapide pour L-Selectin Protein (His tag) (ABIN7197873)

Antigène: L-Selectin (SELL) (Selectin L (SELL))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 98 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette L-Selectin protéine est marqué à la His tag.

Fonction: Recombinant Mouse L-Selectin/SELL Protein (His Tag)

Séquence: Met 1-Asn 332

Attributs du produit: A DNA sequence encoding the extracellular domain (Met 1-Asn 332) of mouse SELL (NP_035476.1) precursor was fused with a polyhistidine tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: L-Selectin (SELL) (Selectin L (SELL))

Autre désignation: L-Selectin/SELL

Sujet:

Background: L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.

Synonym: L-selectin;Sell;CD62 antigen-like family member L;Leukocyte adhesion molecule 1;LECAM1;Lymph node homing receptor;Lymphocyte antigen 22;CD62L;LECAM-1;Lnhr;Ly-22;Ly-m22;Lyam-1;Lyam1

Poids moléculaire: 34.7 kDa

NCBI Accession: NP_035476