SMAD5 Protein (AA 2-465) (His-GST)

N° du produit ABIN7320168

Cette protéine Recombinant SMAD5 est produite dans Baculovirus infected Insect Cells.

Aperçu rapide pour SMAD5 Protein (AA 2-465) (His-GST) (ABIN7320168)

Antigène: SMAD5 (SMAD, Mothers Against DPP Homolog 5 (SMAD5))

Type de proteíne: Recombinant

Origine: Souris

Source: Baculovirus infected Insect Cells

Pureté: > 90 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 2-465

Purification/Conjugué: Cette SMAD5 protéine est marqué à la His-GST.

Fonction: Recombinant Mouse Smad5 Protein (His & GST Tag)

Séquence: Thr2-Ser465

Attributs du produit: A DNA sequence encoding the mouse SMAD5 (P97454) (Thr2-Ser465) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0, 10 % glycerol
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: SMAD5 (SMAD, Mothers Against DPP Homolog 5 (SMAD5))

Autre désignation: Smad5

Sujet: 1110051M15Rik,AI451355,Dwf-C,Madh5,MusMLP,SMAD5 is a member of the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. It is also involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.

Poids moléculaire:

Calculated MW: 79.9 kDa

Observed MW: 75-88 kDa

UniProt: P97454