STUB1 Protéine
Aperçu rapide pour STUB1 Protéine (ABIN7318418)
Antigène
Voir toutes STUB1 ProtéinesType de proteíne
Origine
Source
Pureté
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Fonction
- Recombinant Human STUB1 Protein
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Séquence
- Met 1-Tyr303
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Attributs du produit
- Recombinant Human E3 Ubiquitin-Protein Ligase CHIP is produced by our E.coli expression system and the target gene encoding Met1-Tyr303 is expressed.
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niveau d'endotoxine
- < 1.0 EU per μg as determined by the LAL method.
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!Découvrez nos protéines personnalisées prédéfinies et nos services de protéines sur mesure !ProduitSystème d'expressionConjuguéOriginPrix à partir deSystème d'expression HEK-293 CellsConjugué His tagOrigin HumanPrix à partir de 13.711,36 €Système d'expression Cell-free protein synthesis (CFPS)Conjugué Strep TagOrigin HumanPrix à partir de 20.480,57 €Votre projet nécessite-t-il une personnalisation supplémentaire ? Contactez-nous et découvrez nos solutions protéiques sur mesure
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STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-304) protein (His tag)
custom-made STUB1 Origine: Souris Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (His tag)custom-made STUB1 Origine: Humain Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (His-IF2DI Tag)STUB1 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) (AA 1-303) protein (GST tag)STUB1 Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AP, AA
STIP1 Homology and U-Box Containing Protein 1 (STUB1) protein (Myc-DYKDDDDK Tag)STUB1 Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Restrictions
- For Research Use only
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Format
- Frozen, Liquid
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Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
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Stock
- -20 °C
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Stockage commentaire
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))
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Autre désignation
- STUB1
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Sujet
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Background: E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.
Synonym: E3 Ubiquitin-Protein Ligase CHIP, Antigen NY-CO-7, CLL-Associated Antigen KW-8, Carboxy Terminus of Hsp70-Interacting Protein, STIP1 Homology and U Box-Containing Protein 1, STUB1, CHIP
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Poids moléculaire
- 34.9 kDa
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UniProt
- Q9UNE7
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Pathways
- Regulation of Hormone Metabolic Process, Response to Water Deprivation
Antigène
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