TXNDC17 Protéine

N° du produit ABIN7198224

Détail du produit

Antigène: TXNDC17 (Thioredoxin Domain Containing 17 (TXNDC17))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Fonction: Recombinant Human TXNDC17/TRP14/TXNL5 Protein

Séquence: Met 1-Asp 123

Attributs du produit: A DNA sequence encoding the mature form of human TXNDC17 (Q9BRA2) (Met 1-Asp 123) was expressed and purified, with an initial Met.

Pureté: > 97 % as determined by reducing SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TXNDC17 (Thioredoxin Domain Containing 17 (TXNDC17))

Autre désignation: TXNDC17//TXNL5 (TXNDC17 Produits)

Synonymes: TRP14 Protein, TXNL5 Protein, 4831443O22Rik Protein, D11Ertd672e Protein, Txnl5 Protein, txnl5 Protein, zgc:91920 Protein, thioredoxin domain containing 17 Protein, TXNDC17 Protein, Txndc17 Protein, txndc17 Protein

Sujet:

Background: Cell surface A33 antigen, also known as glycoprotein A33, is a single-pass type I  membrane protein which is expressed in normal gastrointestinal epithelium and in 95% of colon cancers. GPA33 contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. Intracellular traffic and recycling to the cell surface appear to play a major role in GPA33 function and to have an influence on its surface density superseding translational regulation. GPA33 has become a promising target of immunologic therapy strategies, but its biologic function and potential role in tumorigenesis are unknown. EpCAM protein and GPA33 mRNA expressions are specific and sensitive markers of Barrett's metaplasia (BM). GPA33 may also play a role in cell-cell recognition and signaling.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Synonym: TRP14;TXNL5

Poids moléculaire: 13.9 kDa

UniProt: Q9BRA2