Thrombomodulin Protein (THBD) (His tag)

N° du produit ABIN7198229

Protéine Recombinant Thrombomodulin exprimée dans HEK-293 Cells.

Aperçu rapide pour Thrombomodulin Protein (THBD) (His tag) (ABIN7198229)

Antigène: Thrombomodulin (THBD)

Type de proteíne: Recombinant

Origine: Rat

Source: HEK-293 Cells

Pureté: > 90 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette Thrombomodulin protéine est marqué à la His tag.

Fonction: Recombinant Rat Thrombomodulin Protein (His Tag)

Séquence: Met1-Ser517

Attributs du produit: A DNA sequence encoding the rat THBD (O35370) (Met1-Ser517) was expressed with a polyhistidine tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: Thrombomodulin (THBD)

Autre désignation: Thrombomodulin

Sujet:

Background: Thrombomodulin, also known as THBD(CD141), is an integral membrane protein which reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. Thrombomodulin also regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene have also been reported to be associated with atypical hemolytic-uremic syndrome.

Synonym: THBD

Poids moléculaire: 55.2 kDa

UniProt: O35370