TLK2 Protein (His-GST)

N° du produit ABIN7317072

Cette protéine Recombinant TLK2 est exprimée dans Baculovirus infected Insect Cells.

Aperçu rapide pour TLK2 Protein (His-GST) (ABIN7317072)

Antigène: TLK2 (Tousled-Like Kinase 2 (TLK2))

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette TLK2 protéine est marqué à la His-GST.

Fonction: Recombinant Human TLK2/PKU-ALPHA Protein (His&GST Tag)

Séquence: Leu 397-Asn 772

Attributs du produit: A DNA sequence encoding the amino acids (Leu 397-Asn 772) of human TLK2 (Q86UE8-1) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied as sterile solution of 20 mM Tris, 500 mM NaCl, 0.5 mM PMSF, pH 8.0

Agent conservateur: PMSF

Stock: -20 °C

Stockage commentaire: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Date de péremption: 6 months

Détail du antigène

Antigène: TLK2 (Tousled-Like Kinase 2 (TLK2))

Autre désignation: TLK2/PKU-ALPHA

Sujet: HsHPK,PKU-ALPHA,Serine / threonine-protein kinase tousled-like 2, also known as PKU-alpha, Tousled-like kinase 2 and TLK2, is a nucleus protein which belongs to theprotein kinase superfamily and Ser/Thr protein kinase family. The tousled-like kinases are an evolutionarily conserved family of proteins implicated in DNA repair, DNA replication and mitosis in metazoans and plants. Their absence from the yeasts and other eukaryotic 'microbes' suggests a specific role for them in the development of multicellular organisms. Tousled-like kinase 2 / TLK2 is widely expressed. It is present in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle. It is also found in adult cell lines. Tousled-like kinase 2 / TLK2 contains oneprotein kinase domain. Tousled-like kinase 2 / TLK2 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.

Poids moléculaire:

Calculated MW: 71.3 kDa

Observed MW: 65 kDa

ID gène: 11011

UniProt: Q86UE8