TCN2 Protein (His tag)

N° du produit ABIN7198283

Protéine Recombinant TCN2 exprimée dans HEK-293 Cells.

Aperçu rapide pour TCN2 Protein (His tag) (ABIN7198283)

Antigène: TCN2 (Transcobalamin II (TCN2))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette TCN2 protéine est marqué à la His tag.

Fonction: Recombinant Mouse TCN2 Protein (His Tag)

Séquence: Met 1-Trp 430

Attributs du produit: A DNA sequence encoding the mouse TCN2 (O88968) (Met 1-Trp 430) was expressed, with a C-terminal polyhistidine tag.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: TCN2 (Transcobalamin II (TCN2))

Autre désignation: TCN2

Sujet: AW208754,Tcn-2,Transcobalamin II, also known as TCN2 and TC II, is a plasma protein that binds cobalamin (Cbl, vitamin B12) as it is absorbed in the terminal ileum and distributes to tissues. The circulating transcobalamin II-cobalamin complex binds to receptors on the plasma membrane of tissue cells and is then internalized by receptor-mediated endocytosis. Transcobalamin II is a non-glycolated secretory protein of molecular mass 43 kDa. Its plasma membrane receptor (TC II-R) is a heavily glycosylated protein with a monomeric molecular mass of 62 kDa. Human TCN2 gene is composed of nine exons and eight introns spanning approximately 20 kb with multiple potential transcription start sites. A number of genetic abnormalities are characterized either by a failure to express TCN2 or by synthesis of an abnormal protein. The TCN2 deficiency results in cellular cobalamin deficiency, an early onset of megaloblastic anaemia, and neurological abnormalities.

Poids moléculaire:

Calculated MW: 47.0 kDa

Observed MW: 42 kDa

UniProt: O88968