TGFB3 Protéine

N° du produit ABIN7319107

Cette protéine Recombinant TGFB3 est produite dans Human Cells.

Aperçu rapide pour TGFB3 Protéine (ABIN7319107)

Antigène: TGFB3 (Transforming Growth Factor, beta 3 (TGFB3))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Human Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Fonction: Recombinant Human TGFB3 Protein (Active)

Séquence: Ala301-Ser412(Tyr340Phe)

Attributs du produit: Recombinant Human/Mouse Transforming Growth Factor beta 3 is produced by our Mammalian expressionsystem and the target gene encoding Ala301-Ser412(Tyr340Phe) is expressed.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Biological Activity Comment: Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 mouse T cells.  The ED50 for this effect is 10-80 pg/ml.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 4 mM HCl.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TGFB3 (Transforming Growth Factor, beta 3 (TGFB3))

Autre désignation: TGFB3

Sujet:

Background: Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3 becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate.

Synonym: Transforming growth factor beta-3,TGFB3,TGF-beta-3,Latency-associated peptide,LAP

Poids moléculaire: 12.7 kDa

UniProt: P10600

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus