TTR Protein (His tag)

N° du produit ABIN7319108

Protéine Recombinant TTR exprimée dans Human Cells.

Aperçu rapide pour TTR Protein (His tag) (ABIN7319108)

Antigène: TTR (Transthyretin (TTR))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette TTR protéine est marqué à la His tag.

Fonction: Recombinant Human Transthyretin/TTR Protein (His Tag)

Séquence: Gly21-Glu147

Attributs du produit: Recombinant Human Transthyretin is produced by our Mammalian expression system and the target gene encoding Gly21-Glu147 is expressed with a 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: TTR (Transthyretin (TTR))

Autre désignation: Transthyretin/TTR

Sujet:

Background: Transthyretin is a secreted and cytoplasm protein which belongs to the Transthyretin family. Transthyretin is detected in serum and cerebrospinal fluid (at protein level). It is highly expressed in choroid plexus epithelial cells. It is also detected in retina pigment epithelium and liver. Each monomer of Transthyretin has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel. Defects in Transthyretin are the cause of amyloidosis type 1 (AMYL1) which is a hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system.

Synonym: Transthyretin, ATTR, Prealbumin, TBPA, TTR, PALB,CTS,CTS1,HEL111

Poids moléculaire: 14.8 kDa

UniProt: P02766

Pathways: Hormone Transport