VNN1 Protein (His tag)

N° du produit ABIN7320101

Cette protéine Recombinant VNN1 est produite dans HEK-293 Cells.

Aperçu rapide pour VNN1 Protein (His tag) (ABIN7320101)

Antigène: VNN1 (Vanin 1 (VNN1))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Pureté: > 97 % as determined by SDS-PAGE

Détail du produit

Purification/Conjugué: Cette VNN1 protéine est marqué à la His tag.

Fonction: Recombinant Mouse VNN1/Vanin-1 Protein (His Tag)

Séquence: Met 1-Ser 487

Attributs du produit: A DNA sequence encoding the mouse VNN1 (Q9Z0K8) (Met 1-Ser 487), without the pro peptide, was fused with a polyhistidine tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg of the protein as determined by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: VNN1 (Vanin 1 (VNN1))

Autre désignation: VNN1/Vanin-1

Sujet:

Background: Pantetheinase, also known as Pantetheine hydrolase, Vascular non-inflammatory molecule 1, Vanin-1, and VNN1, is a cell membrane protein which belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 contains one CN hydrolase domain. It is widely expressed with higher expression in spleen, kidney and blood. It is overexpressed in lesional psoriatic skin. Vanin-1 is also a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress. Vanin-1 is expressed by enterocytes, and its absence limits intestinal epithelial cell production of proinflammatory signals. Vanin-1 regulates late adhesion steps of thymus homing under physiological, noninflammatory conditions. The early impact of vanin-1 deficiency on tumor induction was directly correlated to the amount of inflammation and subsequent epithelial proliferation rather than cell death rate. Vanin-1 Molecule was shown to be involved in the control of thymus reconstitution following sublethal irradiation.

Synonym: V-1

Poids moléculaire: 53.4 kDa

UniProt: Q9Z0K8

Pathways: Negative Regulation of intrinsic apoptotic Signaling