DDK-1 protein (His tag,Biotin)

N° du produit ABIN7319922

Protéine Recombinant exprimée dans Human Cells.

Aperçu rapide pour DDK-1 protein (His tag,Biotin) (ABIN7319922)

Antigène: DDK-1

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Pureté: >95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: His tag,Biotin

Fonction: Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Avi-6His) Biotinylated

Séquence: Thr32-His266

Attributs du produit: Biotinylated Recombinant Human Dickkopf-related protein 1 is produced by our Mammalian expression system and the target gene encoding Thr32-His266 is expressed with a Avi, 6His tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Commentaires:

35-50 kDa

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: DDK-1

Sujet:

Background: Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Synonym: Dickkopf-related protein 1, Dickkopf-1, Dkk-1

Poids moléculaire: 28.4 kDa

UniProt: O94907