ANGPTL3 Protein (Fc Tag)

N° du produit ABIN7319869

Cette protéine Recombinant ANGPTL3 est produite dans Human Cells.

Aperçu rapide pour ANGPTL3 Protein (Fc Tag) (ABIN7319869)

Antigène: ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))

Type de proteíne: Recombinant

Origine: Humain

Source: Human Cells

Pureté: >95 % as determined by reducing SDS-PAGE.

Détail du produit

Purification/Conjugué: Cette ANGPTL3 protéine est marqué à la Fc Tag.

Fonction: Recombinant Human Angiopoietin-related Protein 3/ANGPTL3 (C-Fc)

Séquence: Ser17-Pro220

Attributs du produit: Recombinant Human Angiopoietin-related Protein 3 is produced by our Mammalian expression system and the target gene encoding Ser17-Pro220 is expressed with a Fc tag at the C-terminus.

niveau d'endotoxine: < 1.0 EU per μg as determined by the LAL method.

Information d'application

Commentaires:

60-70 kDa

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, 5 % Trehalose, pH 7.4.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Détail du antigène

Antigène: ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))

Autre désignation: Angiopoietin-related protein 3

Sujet:

Background: Angiopoietin-like 3 (ANGPTL3) is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Full length ANGPTL3 circulates in the plasma as do the proteolytically separated N-and C-terminal segments containing the coiled coil domain and fibrinogen-like domains,respectively. ANGPTL3 directly inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), enzymes responsible for hydrolyzing circulating triglycerides and HDL phospholipids. ANGPTL3 promotes an increase in circulating triglyceride levels without altering VLDL or HDL secretion or uptake. ANGPTL3 expression in vivo is up-regulated by LXR agonists and down-regulated by insulin, leptin, and agonists of TRβ or PPARβ.

Synonym: Angiopoietin-related protein 3, ANGPTL3, Angiopoietin-5, ANG-5, Angiopoietin-like protein 3, ANGPT5

Poids moléculaire: 50.7 kDa

UniProt: Q9Y5C1