PEA15 Protéine
Aperçu rapide pour PEA15 Protéine (ABIN7318180)
Antigène
Voir toutes PEA15 ProtéinesType de proteíne
Origine
Source
Pureté
-
-
Fonction
- Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15 Protein
-
Séquence
- Met 1-Ala130
-
Attributs du produit
- Recombinant Human Phosphoprotein Enriched in Astrocytes of 15 kDa is produced by our E.coli expression system and the target gene encoding Met1-Ala130 is expressed.
-
Stérilité
- 0.2 μm filtered
-
niveau d'endotoxine
- < 1.0 EU per μg of the protein as determined by the LAL method.
-
Biological Activity Comment
- Not validated for activity
-
-
Vous souhaitez d'autres options pour ce Protein ?
!Découvrez nos protéines personnalisées prédéfinies et nos services de protéines sur mesure !ProduitSystème d'expressionConjuguéOriginPrix à partir deSystème d'expression HEK-293 CellsConjugué His tagOrigin HumanPrix à partir de 11.737,02 €Système d'expression Cell-free protein synthesis (CFPS)Conjugué Strep TagOrigin HumanPrix à partir de 15.754,29 €Votre projet nécessite-t-il une personnalisation supplémentaire ? Contactez-nous et découvrez nos solutions protéiques sur mesure
-
phosphoprotein Enriched in Astrocytes 15 (PEA15) (AA 1-130) protein (His tag)
custom-made PEA15 Origine: Humain Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
phosphoprotein Enriched in Astrocytes 15 (PEA15) (AA 1-130) protein (His tag)custom-made PEA15 Origine: Souris Hôte: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
phosphoprotein Enriched in Astrocytes 15 (PEA15) (AA 1-130) protein (GST tag)PEA15 Origine: Humain Hôte: Wheat germ Recombinant AP, AA, ELISA, WB
phosphoprotein Enriched in Astrocytes 15 (PEA15) protein (Myc-DYKDDDDK Tag)PEA15 Origine: Humain Hôte: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Buffer
-
Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
Stock
- 4 °C,-20 °C,-80 °C
-
Stockage commentaire
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
Date de péremption
- 12 months
-
-
- PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
-
Autre désignation
- PEA15
-
Sujet
- 15 kDa Phosphoprotein Enriched in Astrocytes,Astrocytic Phosphoprotein PEA-15,PEA15,PED,Phosphoprotein Enriched in Diabetes,Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.
-
Poids moléculaire
-
Calculated MW: 15.3 kDa
Observed MW: 12-16 kDa
-
ID gène
- 8682
-
UniProt
- Q15121
Antigène
-
