Recombinant Humain IgG2 Isotype Control

N° du produit ABIN7211742

Aperçu rapide pour Recombinant Humain IgG2 Isotype Control (ABIN7211742)

Antigène: IgG2

Type d'anticorp: Recombinant Antibody

Application: Isotype Control (IsoC), In vivo Studies (in vivo)

Classe de qualité: In vivo Grade

Isotype: IgG2

Détail du produit

Reactivité: Humain

Hôte: Human

Expression System: Mammalian cells

Fonction: In Vivo Grade Recombinant Human IgG2 Fc Protein

Attributs du produit: Human Fc (IgG2) is the tail region of an immunoglobulin G2 (IgG2) that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. The ~230 amino acid fragment generally exists as a dimer, although under reducing conditions, it exists as a monomer. It is the basis of prolonged pharmacokinetics of antibodies and is commonly used as a fusion to extend half-life of fusion proteins. IgG2 has a shorter hinge than IgG1, with 12 amino acid residues and four disulfide bridges at the Fab base. The hinge region of IgG2 also lacks a glycine residue, which along with its shortness almost completely prevents rotation and restricts lateral movement of the Fabs.

Purification: Protein A or G affinity column

Pureté: >95 % by SDS-PAGE under reducing conditions

Stérilité: Sterile filtered

niveau d'endotoxine: < 1 EU per 1 mg of the protein by the LAL method

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4

Stock: 4°C,-20 °C

Stockage commentaire: 1 month from date of receipt, 2 to 8°C as supplied. 3 months from date of receipt, -20°C to -70°C as supplied.

Date de péremption: 3 months

Détail du antigène

Antigène: IgG2

Classe de substances: Antibody