Factor XI Protein (AA 19-625) (His tag)

N° du produit ABIN7274693

Protéine Recombinant Factor XI exprimée dans HEK-293 Cells.

Aperçu rapide pour Factor XI Protein (AA 19-625) (His tag) (ABIN7274693)

Antigène: Factor XI (F11) (Coagulation Factor XI (F11))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Détail du produit

Attributs du protein: AA 19-625

Purification/Conjugué: Cette Factor XI protéine est marqué à la His tag.

Fonction: Human Coagulation factor XI Protein

Séquence: Glu19-Val625

Attributs du produit: Recombinant Human Coagulation factor XI Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu19-Val625.

Stérilité: 0.22 μm filtered

niveau d'endotoxine: Less than 1EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22 μm filtered solution in 25 mM HEPES, 150 mM NaCl ( pH 7.5). Normally 8 % trehalose is added as protectant before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Factor XI (F11) (Coagulation Factor XI (F11))

Autre désignation: Coagulation factor XI

Sujet: Coagulation factor (F)XI has been described as a component of the early phase of the contact pathway of blood coagulation, acting downstream of factor XII.In contrast to its mild hemostatic activities, FXI is known to play a significant role in thrombosis, as it is a demonstrated independent risk factor for deep vein thrombosis, ischemic stroke, and myocardial infarction. A better understanding of the varied and complex role of FXI in both thrombosis and hemostasis will help to allow better prediction of bleeding risk in FXI-deficient patients and also informing the development of targeted agents to inhibit the thrombotic activities of FXI while preserving hemostasis.

Poids moléculaire: 69.1 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result.

UniProt: P03951-1