CCR8 Protein (AA 1-35) (mFc Tag)

N° du produit ABIN7490607

Protéine Recombinant CCR8 exprimée dans HEK-293 Cells.

Aperçu rapide pour CCR8 Protein (AA 1-35) (mFc Tag) (ABIN7490607)

Antigène: CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Application: Affinity Measurement (AM), Antibody Drug Assay (ADA), Immunoassay (IA), Screening Assay (ScA)

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Détail du produit

Attributs du protein: AA 1-35

Purification/Conjugué: Cette CCR8 protéine est marqué à la mFc Tag.

Fonction: Recombinant human CCR8 protein with C-terminal mouse Fc tag

Specificité: CCR8(Met1-Lys35) mFc(Pro99-Lys330)

Attributs du produit: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Information d'application

Indications d'application: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Commentaires:

The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))

Autre désignation: CCR8

Sujet: CCR-8,CMKBRL2,CKR-L1,GPRCY6,TER1,CDw198
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]

Poids moléculaire: predicted molecular mass of 30.2 kDa after removal of the signal peptide. The apparent molecular mass of CCR8-mFc is 33-55 kDa due to glycosylation.

UniProt: P51685