IL-23 alpha & IL-12 beta Protéine

N° du produit ABIN7488786

Cette protéine Recombinant IL-23 alpha & IL-12 beta est produite dans HEK-293 Cells.

Aperçu rapide pour IL-23 alpha & IL-12 beta Protéine (ABIN7488786)

Antigène: IL-23 alpha & IL-12 beta

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Pureté: 95 %

Classe de qualité: Premium grade

Détail du produit

Fonction: Human IL-23 alpha & IL-12 beta Heterodimer Protein, premium grade

Séquence: Ile 23 - Ser 328 (IL-12B) & Arg 20 - Pro 189 (IL-23A)

Attributs du produit: Human IL-23A&IL-12B Heterodimer Protein, premium grade is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Ser 328 (IL-12B) & Arg 20 - Pro 189 (IL-23A) (Accession # P29460-1 (IL-12B) & Q9NPF7-1 (IL-23A).

niveau d'endotoxine: 0.1 EU per μg

Information d'application

Commentaires:

This protein carries no "tag". () The protein has a calculated MW of 55.0 kDa. The protein migrates as 60-65 kDa and 116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: IL-23 alpha & IL-12 beta

Sujet: Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Poids moléculaire: 55.0 kDa