CD69 Protein (CD69) (AA 63-199) (GST-His-Tag)

N° du produit ABIN7505323

Cette protéine Recombinant CD69 est produite dans Escherichia coli (E. coli).

Aperçu rapide pour CD69 Protein (CD69) (AA 63-199) (GST-His-Tag) (ABIN7505323)

Antigène: CD69

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Pureté: > 95 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 63-199

Purification/Conjugué: Cette CD69 protéine est marqué à la GST-His-Tag.

Séquence: Val 63-Lys 199

Attributs du produit: A DNA sequence encoding the Human CLEC2C/CD69 protein (Q07108) (Val 63-Lys 199) was expressed with a N-GST&C-His tag.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: CD69

Autre désignation: CLEC2C

Sujet:

Abbreviation: CLEC2C,CD69

Target Synonym: arly activation antigen CD69,Activation inducer molecule,AIM,BL-AC/P26,C-type lectin domain family 2 member C,EA1,Early T-cell activation antigen p60,GP32/28,Leukocyte surface antigen Leu-23,MLR-3,CD69,CLEC2C

Background: Early activation antigen CD69, also known as activation inducer molecule (AIM), is a single-pass type II membrane protein. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. It is one of the earliest cell surface antigens expressed by T cells following activation. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. CD69 is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator , potentially important in the activation and differentiation of a wide variety of hematopoietic cells. This membrane molecule transiently expresses on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients.

Poids moléculaire:

Calculated MW: 39.96 kDa

Observed MW: 40 kDa

UniProt: Q07108